A novel and rapid method to screen for β-lactamase inhibitors
نویسندگان
چکیده
Based on starch-iodine agar plate, a novel screening method that can be used to screen for β-lactamase inhibitors from extracts of herbs is established. The extracts of 100 traditional Chinese medicines were screened for βlactamase inhibitors by this method. The inhibition rates of the Rheum palmatum L., Schisandra chinensis (Turcz.) Baill., Hypericum japonicum Thunb., Paederia scandens (Lour.) Merr., Oxalis corniculate L., Lycopodium clavatum L. and Salix babylonica L. were found to be 60%. No extracts among these 100 samples show powerful inhibiting activities against β-lactamase. The novel screening method is easy and cheap and provides a clear visual result. It is suitable for large-scale screening of plant extracts that can inhibit the βlactamases.
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